More Efficient Drug Delivery Within The Brain By Utilising Lat1
Express Pharma|October 01-15, 2019
By utilising the new LAT1-prodrug approach, it is possible to achieve drug concentrations relevant for the pharmacological effects in the diseased brain, which has been one of the major challenges to overcome in the CNS-drug development
More Efficient Drug Delivery Within The Brain By Utilising Lat1

.

According to a new study carried out at the University of Eastern Finland, the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain. By converting drug molecules temporarily into prodrugs, derivatives that can utilize LAT1 for cell entry and subsequently release the active parent drug within the target cells. This way one can achieve many times higher concentrations compared to the treatment with the parent drugs alone, which cannot utilize LAT1. This is very important, particularly in a situation where the final target protein is located inside the cells. This study was published in Scientific Reports at the beginning of September.

هذه القصة مأخوذة من طبعة October 01-15, 2019 من Express Pharma.

ابدأ النسخة التجريبية المجانية من Magzter GOLD لمدة 7 أيام للوصول إلى آلاف القصص المتميزة المنسقة وأكثر من 9,000 مجلة وصحيفة.

هذه القصة مأخوذة من طبعة October 01-15, 2019 من Express Pharma.

ابدأ النسخة التجريبية المجانية من Magzter GOLD لمدة 7 أيام للوصول إلى آلاف القصص المتميزة المنسقة وأكثر من 9,000 مجلة وصحيفة.

المزيد من القصص من EXPRESS PHARMA مشاهدة الكل
Harnessing data analytics to propel drug discovery and development in 2025
Express Pharma

Harnessing data analytics to propel drug discovery and development in 2025

As the pharma landscape evolves, data analytics will be at the forefront of drug discovery and development, transforming traditional methods. By leveraging data-driven insights, companies can expedite R&D, optimise clinical trials, and personalise treatments, bringing life-saving therapies to market more efficiently, explains Biju Davis, SVP, Engineering, Model N

time-read
4 mins  |
December 2024
Strengthening our presence within APAC through increased penetration is a key focus
Express Pharma

Strengthening our presence within APAC through increased penetration is a key focus

Aanchal Tomar, Executive Director, Asia Pacific, Lonza Capsules Health Ingredients speaks about Lonza Capsules Health Ingredients’ strategic growth, challenges, and sustainability initiatives in the APAC market, showcasing their innovative capsule solutions and health ingredients that cater to the region's diverse pharmaceutical and nutraceutical needs, in an interview with Express Pharma

time-read
4 mins  |
December 2024
Responsible Sourcing and Manufacturing: Growing towards a sustainable future with Lonza
Express Pharma

Responsible Sourcing and Manufacturing: Growing towards a sustainable future with Lonza

In response to the establishment of environmental impact targets by the pharmaceutical industry, Lonza promotes responsible sourcing practices, sustainable manufacturing standards, and renewable energy utilisation showcasing that responsible manufacturing can assist our customers to reach their sustainability goals, highlights Christine Lebeault, Head of Applied Sustainability, Lonza Capsules and Health Ingredients

time-read
3 mins  |
December 2024
Rethinking R&D to balance efficiency, innovation and sustainability
Express Pharma

Rethinking R&D to balance efficiency, innovation and sustainability

In an era of skyrocketing research costs and complex drug delivery challenges, pharma industry leaders share their insights on adopting advanced technologies, data-driven decision-making, and sustainable practices to optimise R&D and drive impactful therapies to market

time-read
5 mins  |
December 2024
Powerful Process Control with IND500x Weighing Indicators
Express Pharma

Powerful Process Control with IND500x Weighing Indicators

Ensuring consistent quality in hazardous environments, particularly in Ex-Areas (Zone 1/21, Division 1), is a critical aspect of industrial operations. The IND500x weighing indicators from METTLER TOLEDO provide a robust solution for these challenging settings, offering optimized safety and productivity.

time-read
1 min  |
November 2024
Ensuring clean room integrity with prime clean reset high-speed doors
Express Pharma

Ensuring clean room integrity with prime clean reset high-speed doors

Prime Clean Reset high-speed doors ensure airtight seals, minimising air permeability and contamination in clean rooms. Designed for sensitive environments, they enhance operational efficiency and meet rigorous regulatory standards, making them ideal for pharmaceutical and biotech industries

time-read
3 mins  |
November 2024
Complete environmental monitoring solution - testo Saveris Pharma
Express Pharma

Complete environmental monitoring solution - testo Saveris Pharma

There are several critical applications in the industry like research and development that demand for continuous & reliable monitoring of important environmental parameters.

time-read
3 mins  |
November 2024
Adaptive Manufacturing:-The new flexibility in medical device assembly
Express Pharma

Adaptive Manufacturing:-The new flexibility in medical device assembly

Unlike traditional, rigid production lines, B&R's adaptive machines seamlessly adjust to the requirements of each device, dynamically adapting to each unique process

time-read
3 mins  |
November 2024
Reshaping pharma safety with active packaging innovations
Express Pharma

Reshaping pharma safety with active packaging innovations

CILICANT is revolutionising active packaging with solutions tailored for the most sensitive formulations. Meet the innovators driving stability, safety, and impurity control in pharma packaging at CPhI India

time-read
1 min  |
November 2024
UNLOCKING GROWTH FRONTIERS
Express Pharma

UNLOCKING GROWTH FRONTIERS

Vadodara Pharma Summit 2024 brought together industry leaders and experts to highlight the city's pivotal role in India's pharma landscape and explore collaborative strategies to strengthen India's pharma innovation ecosystem

time-read
9 mins  |
November 2024