A significant boost to the Indian economy is expected over the next five years by the foreign and domestic investments being made in the preclinical CRO segment. In an interaction with BioSpectrum Dr Satinder Singh, Associate Director, DMPK Aragen Life Sciences, shared his insights about future growth drivers of preclinical CROs based out of India.
What is Preclinical CRO?
Preclinical is a stage of drug development that ensues before clinical trials (testing in humans) and during which drug potency, efficacy, pharmacokinetics, tolerability and safety data are collected, in laboratory settings to determine a starting, safe dose for FIH study, and forecast potential toxicity of the drug product in humans.
The preclinical phase utilises a range of in-vitro platforms and in-vivo animal models to simulating human physiology and generate valuable insights into the biological activity, pharmacological effects, and potential toxicity of investigational drug candidates. Most pharma companies do not want to invest their time and resources in this domain and rather opt for professional expertise extended by the preclinical CROs. Preclinical CROs offer their expertise in the multifaceted management of this initial stage of the compound screening and evaluation process, which includes selection of suitable invitro profiling platforms, animal models, and the execution of pharmacokinetic, efficacy, mutagenicity, genotoxicity and in-vitro and in-vivo toxicity assays.
At Aragen Life Sciences, we support discovery, preclinical profiling and clinical candidate selection of NCEs for example small molecules and TPDs and NBEs for example peptides, mAbs, Oligos, RNA Therapeutics or therapeutic proteins. This also includes drug testing in rodents and non-rodents like minipigs, rabbits, beagle dogs or non-human primates like rhesus or cyno monkeys for assessing the pharmacokinetics, efficacy and safety of lead compounds.
هذه القصة مأخوذة من طبعة October 2024 من BioSpectrum Asia.
ابدأ النسخة التجريبية المجانية من Magzter GOLD لمدة 7 أيام للوصول إلى آلاف القصص المتميزة المنسقة وأكثر من 9,000 مجلة وصحيفة.
بالفعل مشترك ? تسجيل الدخول
هذه القصة مأخوذة من طبعة October 2024 من BioSpectrum Asia.
ابدأ النسخة التجريبية المجانية من Magzter GOLD لمدة 7 أيام للوصول إلى آلاف القصص المتميزة المنسقة وأكثر من 9,000 مجلة وصحيفة.
بالفعل مشترك? تسجيل الدخول
BioPharma's Transformative & Strategic OUTLOOK 2025
The Indian biopharma industry witnessed notable transformative developments and announcements, marked by innovation, regulatory advancements, and market expansion this year. From achieving global recognition in biosimilars to advancing biomanufacturing capabilities and precision therapeutics, the sector has solidified its role as a key player in the global pharmaceutical landscape. This progress underscores India's strategic focus on leveraging its robust infrastructure, skilled talent pool, and government support to meet the evolving demands of the healthcare industry.
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Victor Ambros and Gary Ruvkun win 2024 Nobel Prize in Physiology or Medicine for discovery of microRNA
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"Australia is a great place to do business as we have a superb research community, great partners and very experienced clinical trial units"
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"To achieve our 'Skilled India' vision, we'll train a large number of individuals quickly and to high standards"
Jayant Singh Chaudhary, Union Minister of State (Independent Charge), Skill Development and Entrepreneurship, Government of India, in an interaction with BioSpecturm in Hyderabad, shares his insights on the various initiatives taken up by the Centre for skill development programmes, boosting self-employment.
Digital Innovations in Diabetes Care
Diabetes affects 537 million people globally and is a major contributor to the non-communicable disease NCD) epidemic. Technological tools such as continuous glucose monitors CGMs) and mobile apps are redefining diabetes management. On this World Diabetes Day November 14, 2024), we explore how digital health is transforming diabetes care and the challenges associated with its integration into healthcare systems.