Pfizer shot targets bone marrow

After we are born, production of blood cells starts in the bone marrow

- LIONEL EDDY

Study 1 Matteo Zurlo et al., The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-foetal globin genes in human erythroleukemia K562 cells, bioRvix. doi: https://doi.

org/10.1101/2023.09.07.556634 (7 September 2023).

Study 2 Laura Breda et al., In vivo hematopoietic stem cell modification. by mRNA delivery. Science 381,436443(2023). doi: https://www.science.org/ doi/10.1126/science.ade6967 (27 July 2023).

■ Study 3 - Puccetti, M.; Schoubben, A.; Giovagnoli, S.; Ricci, M. Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? Int. J. Mol. Sci. 2023, 24, 2218. https://doi.org/10.3390/ ijms24032218 (22 January 2023).

Bone marrow makes more than 220 billion new blood cells every day.

Haematopoiesis is the medical term used to describe the process by which our blood cells are formed, develop and mature into their final 'adult' types. The process begins with a haematopoietic stem cell (HSC), which then goes through a series of steps to arrive at the final product a mature blood cell. A mature blood cell would be a red blood cell, a white blood cell such as a lymphocyte, or some other type of blood cell.