Recommendation
• The COVID-19 Treatment Guidelines Panel (the Panel) recommends against the use of low-titer COVID-19 convalescent plasma for the treatment of COVID-19 (AIIb).
* Low-titer COVID-19 convalescent plasma is no longer authorised through the convalescent plasma EUA.
For Hospitalised Patients With COVID-19 Who Do Not Have Impaired Immunity
• The Panel recommends against the use of COVID-19 convalescent plasma for the treatment of COVID-19 in mechanically ventilated patients (AI).
• The Panel recommends against the use of high-titer COVID-19 convalescent plasma for the treatment of COVID-19 in hospitalised patients who do not require mechanical ventilation, except in a clinical trial (AI).
For Hospitalised Patients With COVID-19 Who Have Impaired Immunity
• There are insufficient data for the Panel to recommend either for or against the use of high-titer COVID-19 convalescent plasma for the treatment of COVID-19.
*Observational data including data from case reports, case series, and a retrospective case-control study suggest a benefit of COVID-19 convalescent plasma in patients with various primary and secondary humoral immunodeficiencies.2-16
*Several case reports indicate that patients with impaired humoral immunity may experience persistent SARS-CoV-2 viral replication and therefore, may be at risk for developing viral resistance to SARS-CoV-2 antibodies after treatment with COVID-19 convalescent plasma.17-19
*High-titer convalescent plasma is authorised under the EUA for the treatment of hospitalised patients with COVID-19 and impaired immunity.
For Nonhospitalised Patients With COVID-19
• There are insufficient data for the
Diese Geschichte stammt aus der May 2021-Ausgabe von Future Medicine India.
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Diese Geschichte stammt aus der May 2021-Ausgabe von Future Medicine India.
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