The manic fantasy about a fractured family swept up in an interdimensional adventure also claimed wins for best actress, best director, best-supporting actor, best-supporting actress, best editing and best original screenplay at the 95th Academy Awards ceremony on Sunday night. It was the most nominated film of the night.
Michelle Yeoh has become only the second woman of colour to win the best actress Oscar, following in the footsteps of Halle Berry in 2002.
"For all the little boys and girls who look like me watching tonight, this is a beacon of hope and possibility," Yeoh said. "Ladies, don't ever let anyone tell you you are past your prime."
Ke Huy Quan was named best-supporting actor, beating Barry Keoghan and Judd Hirsch. He has become the first Vietnam-born actor to win an Oscar. This year's awards marked the first time multiple Asian actors won Oscars on the same night.
Jamie Lee Curtis was named best supporting actress for her performance in Everything Everywhere, beating Angela Bassett and Kerry Condon. It was Curtis's first-ever nomination.
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