The GLP-1 scientists, Akiko Iwasaki, Michael J. Fox, Hadiza Galadanci, Vivek Murthy +92 more
Jens Juul Holst, Joel Habener, Svetlana Mojsov, and Dan Drucker PAVING THE WAY FOR WEIGHT-LOSS DRUGS
If [GLP-1 drugs] show benefit for even half of these conditions, then that will be a tremendous win for people struggling with them.' -DAN DRUCKER
Newly powerful weight-loss drugs became the biggest story in health in the past year-and Jens Juul Holst, Joel Habener, Svetlana Mojsov, and Dan Drucker played pivotal roles in making those medications possible. The scientists conducted the early work, beginning in the 1970s, on glucagon-like peptides, or GLPs, that first transformed the treatment of diabetes and now that of obesity.
As with many groundbreaking medical developments, it was a group effort. Holst, at the University of Copenhagen, noticed that after intestinal surgery, patients' levels of insulin soared while their blood-sugar levels dropped; he attributed the changes to several gut-related hormones, including glucagon, which is made in the pancreas. Around the same time, an ocean and a continent away in Boston, Habener and Drucker worked with animals in the lab at Massachusetts General Hospital and identified new types of glucagon hormones that they called GLP-1 and GLP-2. Mojsov, a chemist two floors away, also independently identified the active portion of GLP-1, which is mimicked in the new weight-loss drugs as the key compound in Ozempic and Wegovy (made by Novo Nordisk) and one of two main compounds in Mounjaro and Zepbound (made by Eli Lilly). Mojsov produced large amounts of the peptide and developed antibodies to stick to them. The trio eventually collaborated on critical scientific papers that described the active part of GLP-1 in the guts of rats, and documented that increasing GLP-1 levels corresponded to increasing levels of insulin.
Diese Geschichte stammt aus der May 13, 2024-Ausgabe von Time.
Starten Sie Ihre 7-tägige kostenlose Testversion von Magzter GOLD, um auf Tausende kuratierte Premium-Storys sowie über 8.000 Zeitschriften und Zeitungen zuzugreifen.
Bereits Abonnent ? Anmelden
Diese Geschichte stammt aus der May 13, 2024-Ausgabe von Time.
Starten Sie Ihre 7-tägige kostenlose Testversion von Magzter GOLD, um auf Tausende kuratierte Premium-Storys sowie über 8.000 Zeitschriften und Zeitungen zuzugreifen.
Bereits Abonnent? Anmelden
A Filmmaker's Quest to Unmask Bitcoin's Creator - Who is Bitcoin's founder, Satoshi Nakamoto? the question has perplexed and excited cryptocurrency fans ever since Bitcoin was created by someone with that username in 2009.
Who is Bitcoin’s founder, Satoshi Nakamoto? the question has perplexed and excited cryptocurrency fans ever since Bitcoin was created by someone with that username in 2009.
Unmasking prediabetes - Type 2 diabetes doesn't always arrive with a bang. It can develop slowly but eventually result in marked side effects like extreme thirst and hunger, frequent urination, blurry vision, tingling sensations, and fatigue.
Type 2 diabetes doesn’t always arrive with a bang. It can develop slowly but eventually result in marked side effects like extreme thirst and hunger, frequent urination, blurry vision, tingling sensations, and fatigue.
Animals understand death too - In 2018, field researchers in Uganda came across an unusual sight: a female chimpanzee carrying an infant she had recently given birth to that was affected by albinism, an extremely uncommon condition in this species that gives their fur a striking white color.
In 2018, field researchers in Uganda came across an unusual sight: a female chimpanzee carrying an infant she had recently given birth to that was affected by albinism, an extremely uncommon condition in this species that gives their fur a striking white color.
The Petro State - Colombia's first leftist leader wants to end oil
Last year, Colombian president Gustavo Petro watched in dismay as a political and economic crisis unfolded on the other side of his country’s eastern border. Global powers had imposed sanctions on Venezuela’s oil exports after the country’s autocratic leader, Nicolás Maduro, allegedly A his re-election. As hyperinflation fueled turmoil, millions of refugees poured into Colombia to escape.
Fortress Democracy - Despite efforts at home and abroad to undermine faith in U.S. elections, this year's vote is set to be the most secure and reliable ever. Thank new laws, fail-safes, and courageous election officials
Despite efforts at home and abroad to undermine faith in U.S. elections, this year’s vote is set to be the most secure and reliable ever. Thank new laws, fail-safes, and courageous election officials
The Beauty of Being Alone - There's a lot of fear around spending time alone. Alone time can make people itchy with boredom.
Recent articles and studies warn us about the dangers of loneliness—one 2017 study by Julianne Holt- Lunstad at BYU’s Social Connection and Health Lab claims loneliness is as bad as smoking 15 cigarettes a day. In 2023, U.S. Surgeon General Vivek Murthy published an advisory all about the epidemic of loneliness in America. It details the genuine risks of chronic loneliness, such as increased rates of anxiety and depression, as well as dementia in older adults
What is 'American Malaria' and Are You at Risk? - Few things will leave you feeling quite so icky as returning from a jaunt outside and finding a tick clinging to your skin
Babesiosis, is causing particular concern. The disease is colloquially known as “American malaria,” partly because of its widening spread and partly because of its clinical profile. Like malaria, it can lead to headache, fever, chills, nausea, vomiting, altered mental state, anemia, low blood pressure, respiratory distress, and more.
A strip-club fairy tale with a generous heart
THERE ARE FEW FILMMAKERS AS OPENHEARTED, as stone-soup inventive, as Sean Baker.
Fanfare for the gentle man
IN WE LIVE IN TIME, THE ROMANTIC drama whose slow October rollout has swept up moviegoers in a tidal wave of tears, Andrew Garfield plays a divorced man who finds love in a hopeless place.
On fathers, and the limits of forgiveness
IN 2016, TITUS KAPHAR MADE THE Jerome Project, a short documentary in which he confronts how his father’s abuse and drug use harmed his childhood.
