The Reds will resume their campaign with the ambition of getting back to winning ways after suffering successive defeats prior to the international break. After losing 2-1 to Brighton and Hove Albion in their first away game of the season, the Reds were beaten 3-0 by Liverpool at Old Trafford last time out.
It means Ten Hag and his players are already under a huge degree of pressure to get back on track this weekend.
On paper, it strikes as being a golden opportunity to get three points on the board, with Southampton having lost each of their first three league games.
Ahead of the long trip south, United will be hoping to get at least two significant boosts on the injury front.
Both Luke Shaw and Rasmus Hojlund, neither of whom have featured so far this season, could be in contention to feature in some capacity.
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