The Italian top seed warmed up for next week's US Open in style, biding his time in a hardfought first set before breaking the match open in the second.
Tiafoe, whose game faded after losing the first-set tiebreaker, still made an impression.
The American, who moves into the ranking top-20, saved three match points before Sinner claimed his 15th career title.
Cincinnati is the fifth trophy of 2024 for the 23-year-old Italian, who began the season with an Australian Open crown in Melbourne.
"I'm happy, this was a very difficult week," Sinner said."It was tough mentally but I tried to do my best.
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Heather's Boy prepares for Cape
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Courage wins the day for Atticus
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PIRATES COME UNSTUCK
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Cut Bavuma some slack
Temba Bavuma has often been praised by coaches and teammates for his leadership abilities, but as a specialist batter the Proteas skipper must have been frustrated by his lengthy struggle to convert fifties into centuries.
Proteas keep growing as a unit
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Wallabies far from finished product
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Proteas keep their heads up
With England having secured a 3-0 clean sweep in the T20 International series that concluded at the weekend, Proteas all-rounder Nondumiso Shangase says the national women's team are keeping their heads up as they prepare for a three-match ODI series against the tourists.
Bulls flex their muscles abroad
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Kane ruled out 'for the time being'
Bayern Munich striker Harry Kane (right) has been ruled out \"for the time being\", with a hamstring tear, the club announced yesterday.
'Crazy' win thrills Arteta
London - Mikel Arteta (above) said Arsenal's \"crazy\" 5-2 win at West Ham has catapulted his team back into the Premier League title race.
