Sims, from Rochester in New York, shot to fame in the late 1980s when her single Come Into My Life reached the top 10 in the US and UK. Her first hit, (You Are My) All and All, had reached No 6 in the US dance chart and the top 20 of the UK singles chart.
Sims had been touring in England this summer, and an album was due out this year. Her death was confirmed on social media by family members. The Guardian has contacted Sims' representatives.
Annette Ramsey, one of her siblings, said "my heart is broken" and added on Facebook: "I will always remember the happy times we've shared, the love and support you have given me will not go in vain."
Debbie Sims Hall, another of her sisters, described the late singer as "a beautiful soul inside and out" who "will truly be missed".
Chris Rizik, the publisher of the website SoulTracks, described Sims as a "great talent who sang, wrote and played for us for more than three decades".
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