The request comes as China reopens to foreign visitors post-pandemic, and as its leader, Xi Jinping, calls for more tourism in the region.
A report by the US-based Uyghur Human Rights Project (UHRP) said western tourism in the region risked supporting normalisation of Chinese government policies "intended to destroy Uyghur identity".
China's government has been accused of crimes against humanity and abuses, including torture, via its policies of mass detention, reeducation, surveillance, population control and oppression of religious and cultural expression in the region.
It denies all the accusations, saying its policies are aimed at countering extremism and alleviating poverty.
"Nothing under current conditions in East Turkistan aligns with travel company and industry commitments to protection and empowerment of local communities," the group said, using the traditional name of the region and its title as an independent state between 1944 and 1949.
The UHRP report described tours offered by seven travel firms with offices in western countries. Some were advertising tours for this year and next, while others had not offered any since before the pandemic.
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