The Sharks were more like porpoises at Bath last time out, conceding six tries in a 40-13 defeat having been hit for 47 by Northampton the week before.
Leicester have lost just one Premiership match since Michael Cheika took over as director of rugby but are unbeaten on the road where Exeter and Saracens have been among their victims. Sale have not lost at home in the league since the start of the year.
"They have their bite back," said Sanderson, Sale's director of rugby. "They have the best defence currently, win the most penalties in the scrum, they get back the most balls in the air and score the most tries from a maul. Cheika has given them intent.
"We were a bit toothless against Bath. It is up to us to get our bite back."
Sale reacted to the defeat at Bath, when their defence was broken far too easily, by making a change to the coaching team.
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Gallagher's late brace proves key for Caldy
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Borthwick: It's time to put our foot down
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Watson: I had to quit, I was in so much pain
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Seabrook hat-trick as Saints edge a thriller
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Barritt backing the new boys
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