Lower Myostatin Naturally For Maximum Muscle Growth And Fat Loss
Muscular Development|October 2017

Out of all the molecules in the human body that directly influence muscle size, myostatin is certainly one of the more powerful ones, based on its potent ability to prevent muscle growth. Myostatin is a member of the transforming growth factor-beta (TGF-beta) super family of growth factors where, despite being a growth factor, it actually reduces muscle growth by initiating several pathways that inhibit muscle hypertrophy while stimulating muscle atrophy.

Michael J. Rudolph, Ph.D.
Lower Myostatin Naturally For Maximum Muscle Growth And Fat Loss

More specifically, myostatin inhibits muscle growth by inhibiting the formation of new muscle fibers, a process known as myogenesis , while decreasing mTOR-driven protein synthesis in muscle cells. 

In addition to myostatin’s ability to stop muscle growth, additional scientific evidence highlights myostatin’s capacity to increase body fat, primarily by decreasing sensitivity to the hormone leptin. 3 Given that leptin is a signal to the brain that decreases appetite while simultaneously stimulating the rate of fatty acid oxidation, a decreased sensitivity to leptin brought on by myostatin increases food consumption while decreasing fat burning— causing the unwanted accumulation of body fat.

The “fat increasing” characteristic of myostatin represents one more bona fide reason to want to decrease myostatin function, especially for anyone trying to build a more lean and muscular physique. Interestingly, a number of innovative ways have been discovered that inhibit myostatin activity, conceivably enhancing muscle growth and fat loss in remarkable ways.

LOW-INTENSITY AEROBIC EXERCISE

As expected, lifting weights has been shown to decrease myostatin levels, representing one of the many ways that intense weightlifting triggers muscle growth. However, a study by Hittel et al. 4 unexpectedly showed that low intensity aerobic exercise can also considerably decrease the amount of myostatin— establishing a unique way to manipulate myostatin, supporting muscle growth.

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