The FTSE 250 developer and landlord started construction on its Baker Street scheme on October 21.
It will be made using low-carbon concrete, and the building will run on an all electric heating and cooling system, with renewable electricity.
The site will comprise more than 200,000sq ft of offices, as well as shops and homes.
Derwent announced in 2020 it was planning to create the project speculatively, without having definite business tenants lined up, in the second half of this year.
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