Ageing is a complex biological process which results from accumulation of molecular and cellular damage over time. As we age the skin undergoes few structural and functional changes which is evident as wrinkling, loss of volume and elasticity.
• Ageing is classified into
• Intrinsic – Genetically controlled, inevitable process which occurs with passage of time which is otherwise called Chronological Ageing.
• Extrinsic – Changes which occur due to chronic exposure to sunlight, pollution and life style factors like smoking and alcohol.
• Mechanisms and theories to explain ageing
• Telomere shortening
• Oxidative damage due to ROS
• TGF-Beta/Smad signalling pathway
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