ON A SCREEN ON THE FAR WALL, I COULD SEE A HOLE WHERE THE TUMOR HAD BEEN, AN ALMOST PERFECTLY ROUND MINIATURE PLANET.
One morning at the end of April 2023, Marcela Maus, a cancer researcher at Mass General in Boston, got a call from her colleague Bryan Choi. “He called me, and he’s like, ‘Oh my God, oh my God, oh my God!’ And I’m like, ‘What is going on?’ ” Maus said. Choi, a neurosurgeon with the languid demeanor of a surfer, was not given to outbursts. Maus hung up the phone and hurried over to his office.
The day before, Choi and Maus had treated their first patient in a clinical trial for an aggressive brain cancer called glioblastoma, infusing genetically modified white blood cells directly into the fluid surrounding the brain. They had been up all night worrying, especially after the patient, a 74-yearold man, developed a fever. Choi had ordered an MRI. “We were not looking for the results,” he said. “We were trying to make sure that our patient was okay.”
When Maus got to Choi’s office, images from the MRI were loading on his screen. They stared in wonder: The patient’s tumor, which a few days before had shown up on the scan as a bright blob the size of a strawberry, had almost entirely disappeared. No one had heard of that kind of regression in glioblastoma, especially not overnight. “My first instinct was that there was something wrong with the MRI scanner,” Choi said. But then the follow-up scans looked even better.
Several weeks later, they treated a second patient, a civil engineer from upstate New York named Tom Fraser, and the process repeated itself: the infusion, the fever, and the rapid regression of the tumor. “It was almost like clockwork,” Maus said, still sounding astonished months later. After a third patient had a similar response, she paused the trial and wrote up her results.
A VIAL CONTAINING 10 MILLION OF TOM FRASER'S CAR-T CELLS AT MASS GENERAL CANCER CENTER IN BOSTON.
Esta historia es de la edición July 15-28, 2024 de New York magazine.
Comience su prueba gratuita de Magzter GOLD de 7 días para acceder a miles de historias premium seleccionadas y a más de 9,000 revistas y periódicos.
Ya eres suscriptor ? Conectar
Esta historia es de la edición July 15-28, 2024 de New York magazine.
Comience su prueba gratuita de Magzter GOLD de 7 días para acceder a miles de historias premium seleccionadas y a más de 9,000 revistas y periódicos.
Ya eres suscriptor? Conectar
Early and Often: David Freedlander - Momentum vs. Machine The Trump and Harris campaigns battle it out for every last vote.
WIth two weeks left to go, the contours of the 2024 presidential election are clear: Both campaigns need voters who usually don’t vote, and Kamala Harris needs to bring the Democratic coalition, including its Trump-curious members, back home.While the Republican side plans to spend the remaining days of the contest trying to lure low-propensity voters to the polls, the Harris team will attempt to persuade voters of color to return to its side and will try to increase numbers among white voters in previously red suburbs.
Drowning in Slop - A thriving underground economy is clogging the internet with AI garbage-and it's only going to get worse.
SLOP started seeping into Neil Clarke's life in late 2022. Something strange was happening at Clarkesworld, the magazine. Clarke had founded in 2006 and built into a pillar of the world of speculative fiction. Submissions were increasing rapidly, but “there was something off about them,” he told me recently. He summarized a typical example: “Usually, it begins with the phrase ‘In the year 2250-something’ and then it goes on to say the Earth’s environment is in collapse and there are only three scientists who can save us. Then it describes them in great detail, each one with its own paragraph. And then—they’ve solved it! You know, it skips a major plot element, and the final scene is a celebration out of the ending of Star Wars.” Clarke said he had received “dozens of this story in various incarnations.”
The City Politic- The Other Eric Adams Scandal The NYPD shot a fare evader, a cop, and two bystanders. He defends it.
On Sunday, September 15, Derell Mickles hopped a turnstile, got asked to leave by cops, then entered the subway again ten minutes later through an emergency exit. This was at the Sutter Avenue L station, out by his mother's house, five stops from the end of the line. Police said they noticed he was holding a folded knife. They followed him up the stairs to the elevated train, asking him 38 times to drop the weapon.
Can the Media Survive?
BIG TECH, Feckless Owners, CORD-CUTTERS, RESTIVE STAFF, Smaller Audiences ... and the Return of PRINT?
Status Update
Hannah Gadsby's fascinatingly untidy tour through life after fame and death.
A Matter of Perspective
A Matter of Perspective Steve McQueen's worst film is still a solid WWII drama.
Creator, Destroyer
A retrospective reveals an architect's vision, optimism, and supreme arrogance.
In Praise of Bad Readers
In a time of war, there is a danger in surveying the world as if it were a novel.
Trust the Kieran Culkin Process
First, he nearly dropped out of Oscar hopeful A Real Pain. Then he convinced Jesse Eisenberg to change the way he directs.
The Funniest Vampires on TV
What We Do in the Shadows is coming to an end. Its idiosyncratic brand of comedy may be too.
