The BGT favourites have been facing uphill battles from birth.
Stefan, 40, was born without eyes.
He said: "Something happened while I was developing, which stopped the growth of one of my eyes at a very early stage and resulted in me having no eye in the other socket. I am literally completely blind. I don't even have perception so I am the real deal!"
"Beats me hands down," soprano Denise, 53, grinned. "We're even competitive about how blind we are!" She was born with retinitis pigmentosa, a rare group of diseases that affect the retina.
"I was born with quite a lot of vision," Denise said. "It sort of took a nosedive when I went through puberty, and then another nosedive every time I had a baby.
"And then, when I had chemo two years ago, it just took the rest of it, basically." Denise, who was diagnosed with breast cancer in 2021, ended up losing a chunk of her "favourite" left breast, Thelma. The right one is called Louise, she told the BGT audience to rapturous applause.
"As I was going through cancer treatment, Climb Ev'ry Mountain was always in my head," she said. "It is a really life-affirming, feelgood song." And the couple's rendition brought BGT judge Bruno Tonioli to tears.
Denise's three children from an earlier relationship - Rebecca, 30, Michael, 28 and Sam, 26 are all sighted. "They dodged the bullet," Stefan said. But their child together, Dimitri, 10, has retinitis pigmentosa too. Denise explained: "Even though Stef's eye condition is not related to my condition, it turned out he carries the same damaged gene as me.
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