The Beit Lahiya strike killed at least 22 people, including women and children, health officials said.
More than 30 people were living in the multi-storey building before it was struck, and several family members remained missing as rescue operations continued through the morning, the Palestinian WAFA news agency said.
The Israeli military told Reuters it had carried out a strike targeting Hamas militants near the Kamal Adwan Hospital, which is located between Beit Lahiya and Jabalia, towns on the northern fringe of Gaza under Israeli siege for two months.
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