The report from the Los Angeles County Medical Examiner came nearly seven weeks after Perry, 54, who publicly acknowledged decades of drug and alcohol abuse, was found by his live-in assistant floating face down and lifeless in the jacuzzi of his Los Angeles home.
Toxicology tests found ketamine, a short-acting anaesthetic with hallucinogenic properties, in Perry's body at high levels well within the range typically associated with general anesthesia used in monitored surgical care, the report said.
"Matthew Perry's cause of death is determined to be from the acute effects of ketamine," the autopsy concluded.
Coronary artery disease, the effects of the opioid-addiction medicine buprenorphine, also detected in his system, and drowning were listed as contributing factors in his death, which was ruled an accident.
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