Guardiola's City failed in their protracted attempts to prise the England captain away from Tottenham in the summer of 2021.
The club instead turned their attention to Erling Haaland and this time landed their target, with the Norwegian moving to the Etihad Stadium last year.
In terms of goals, that deal has proved a huge success with the prolific Haaland having netted 31 times in 27 appearances this term.
Guardiola therefore has no reason to dwell on what might have been with Kane, ahead of facing him in north London today, but his admiration for him has not changed.
The City manager said: “We are extremely happy with Erling and, of course, I think Tottenham are extremely happy with Harry Kane.
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