The tourists were backed into a corner after centuries from Shan Masood and Abdullah Shafique put Pakistan in total control at 261 for one in the final session, but a spirited fightback dragged them back to 328 for four at stumps in Multan.
After 56 joyless overs and 253 runs, England picked up Masood and Shafique in quick succession, then added the mercurial Babar Azam as Chris Woakes landed a morale-boosting late blow with the second new ball.
In energy-sapping heat and with a stubbornly unresponsive pitch to work with, things might easily have gone off the rails.
England assistant coach Jeetan Patel said: "I couldn't commend them any more, the toil they put in was high end.
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