Marler's decision to hang up his boots comes three-and-ahalf weeks after he brought his time with England to an end.
The 34-year-old prop had indicated he would continue playing club rugby until the end of the season but he now bows out in front of Quins fans this weekend.
Marler has made 285 appearances for Harlequins since arriving at The Stoop in 2009 and retires with two Gallagher Premiership winners medals.
"The time has come to finally jump off the rollercoaster and walk away from this beautifully brutal game," he said.
"On Friday night I'll play my last ever match for Quins. After all these happy years, it's over.
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