Kyle Walker suffered an injury on international duty that has stopped him from travelling to Madrid for the game, while Nathan Ake pulled up in the first Premier League back against Arsenal and remains sidelined.
Josko Gvardiol has travelled after being withdrawn at half-time against Crystal Palace at the weekend, but didn't train fully with the squad yesterday and was described by Guardiola as a doubt.
Guardiola didn't hide the fact that with Walker out City had lost their best chance of keeping out Vinicius Jr, especially given the England man performed so well in the individual duel last season.
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