Cheshire constabulary said the investigation would examine senior leadership and decision-making to determine if there was criminality at the time of the charges Letby faced.
Letby, 33, is serving a whole-life order after being convicted of the babies' murders and attempted murders at the hospital's neonatal unit in 2015 and 2016.
Announcing the corporate manslaughter investigation, Det Supt Simon Blackwell said: "Following the lengthy trial, subsequent conviction of Lucy Letby and an assessment by senior investigative officers, I can confirm that Cheshire constabulary is carrying out an investigation into corporate manslaughter at the Countess of Chester hospital.
"The investigation will focus on the indictment period of the charges for Lucy Letby, from June 2015 to June 2016, and consider areas, including senior leadership and decision-making, to determine whether any criminality has taken place. At this stage we are not investigating any individuals in relation to gross negligence manslaughter. The investigation is in the very early stages and we are unable to go into any further details...
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