Arguably the most powerful backbencher of his political generation, Brady released a statement to his local newspaper saying it was time to "bring this fascinating and fulfilling chapter of my life to a close".
The MP for Altrincham and Sale West in Greater Manchester since the constituency was created in 1997, Brady has never held ministerial office but has chaired the committee that represents Tory backbenchers since 2010.
During that time he observed four prime ministerial departures - David Cameron, Theresa May, Boris Johnson and Liz Truss - and subsequent elections for a successor, and in three of the cases played a pivotal role in their resignations.
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