Mr Kennedy ran for president in the 2024 election as an independent before dropping out in August and endorsing Trump in exchange for a role in the Republican's administration.
Mr Kennedy, the son and nephew of two titans of Democratic politics, has frequently talked about tackling what he calls the "chronic disease epidemic" of conditions including obesity, diabetes and autism, and reducing chemicals in food.
"The safety and health of all Americans is the most important role of any administration, and HHS will play a big role in helping ensure that everybody will be protected from harmful chemicals, pollutants, pesticides, pharmaceutical products and food additives that have contributed to the overwhelming health crisis in this country," Trump said in a post on social media.
The HHS oversees drug regulation, public health agencies including the Centres for Disease Control and Prevention and health insurance for more than 140 million people, including the poor, those aged 65 and older, and the disabled through Medicare and Medicaid.
HHS had a US$3.09 trillion (S$4.15 trillion) budget for fiscal year 2024, representing 22.8 per cent of the US federal budget.
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