"Immediate action, within days not weeks, is required from all actors who are directly taking part in the conflict, or have influence on its conduct, to avert and alleviate this catastrophic situation," said the independent Famine Review Committee (FRC) in a rare alert.
The warning comes just days ahead of a US deadline for Israel to improve the humanitarian situation in Gaza or face potential restrictions on US military aid.
Israel's mission to the United Nations in New York did not immediately respond to a request for comment.
"If no effective action is taken by stakeholders with influence, the scale of this looming catastrophe is likely to dwarf anything we have seen so far in the Gaza Strip since Oct 7, 2023," the FRC said.
The UN Office for the Coordination of Humanitarian Affairs estimates that there are between 75,000 and 95,000 people still in northern Gaza.
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