IT’S STRANGE THAT we now see America threatened by a plague. Because without plague, America, as we know it, wouldn’t exist.
It may have been the most devastating epidemic in the history of humankind—surpassing in its mortality rates any before or since, including the Black Death in the Europe of the mid-14th century. Smallpox arrived in America with the first Europeans and went on, with several other imported diseases, to wipe out up to 90 percent of the Native population in a relatively short amount of time—millions and maybe tens of millions died.
They were horrible, harrowing deaths. The virus Variola major incubated for two weeks, followed by an intense few days of fever, before the pustules emerged: first in the mouth, throat, and nasal passages, then all over the body, including around the eyes, where they often caused blindness. A human being would struggle for perhaps ten days, covered in these sores, erupting in bloody and pus-filled bumps—and then, with luck, the illness subsided. The sores healed; the pockmarks, highly visible on the face, remained. The residue from these sores was also terribly infectious and lingered on surfaces or cloth for years—but scholars now consider the vast majority of deaths, just like those from covid-19, to have been from human-to-human transmission.
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