In a landmark discovery, researchers at University of California, San Francisco say they’ve identified a gene that links hearing loss to cell death in the inner ear of humans, laying the groundwork for potentially preventing deafness altogether!
Their findings connected animal studies on hearing impairment with a rare type of human-inherited deafness.
They found in both cases mutations to the TMTC4 gene trigger a molecular domino effect called unfolded protein response (UPR) — leading to the loss of vital hair cells in the inner ear. Such hairs are responsible for picking up sound waves and changing them into nerve signals for the brain to interpret.
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