Quins were guided to a fourth win and leadership of the Premiership by the attacking edge of Marcus Smith and a resilient pack that never allowed Leicester to dominate.
The lead changed hands four times after the interval and the contest was only settled by a 71st-minute try from Quins flanker Dino Lamb who had also scored in the first half.
Leicester recalled all their England contingent in a team that showed only six starters from the previous week's defeat at Saracens. Freddie Steward, on the wing instead of in his England, scored two of their three tries.
Quins' assistant coach. Nick Evans felt his team had "earned the win,' but urged his squad not to get ahead of themselves.
"We've got a big game next week against Saracens." "We had to stay in the fight here and we kept grinding away," he added.
To the credit of the teams they produced a refreshing contest - free nearly of prolonged kicking duels that zipped along before a big crowd.
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