The Duke of Sussex, 40, referred to them as "little legends" during his fourth trip back to the UK this year.
Harry beamed as he arrived at the event, which honours the achievements of children battling serious conditions, and displayed his natural way with youngsters.
The duke was upstaged by six-yearold Noah Nicholson - who has cerebral palsy and chronic lung disease as he presented him with the award for the most inspirational child aged four to six.
Recognising the lad's toy animal comforters, he said: "My daughter Lili has these lovies."
Noah playfully grabbed his beard and threw his toys on the floor delighting in seeing the prince pick them up.
Crystal
His mother, Tracey Nicholson, 42, from Grimsby, Lincs, apologised for her son's antics but he replied: "Don't apologise, I love it."
Harry was quizzed on whether he holds a passport by Anya Olweny, 12, named as inspirational sibling.
Another child gave him gifts for his children.
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