Most of the squad picks itself but there are still some big decisions facing Southgate. Here, Standard Sport assesses the selection issues facing the England manager...
What does Southgate do with his wing-backs without Reece James?
Losing James to injury is a major blow, with the Chelsea defender having been nailed on to start at right wing-back.
Kyle Walker is expected to be named in the squad despite not playing since groin surgery on October 6, but it is unclear whether he will be fit for the start of the tournament.
Should Southgate use a 3-4-3 system, then Walker is likely to start on the right of a back-three.
Trent Alexander-Arnold clearly does not have the confidence of the England manager, so Kieran Trippier looks favourite to start at right wing-back.
Luke Shaw will start at left wing-back and Trippier can deputise for him if necessary. If Trippier is the first-choice right wing-back, then Southgate might want to take another left-sided wingback after Ben Chilwell was ruled out with a hamstring injury.
Crystal Palace’s Tyrick Mitchell and Tottenham’s Ryan Sessegnon (far right) are other left-sided options but lack experience at international level.
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