Sam Curran made amends after being thumped for 30 in an over, hit for four sixes and a four by Windies captain Rovman Powell, with 50 off 32 balls, having been elevated to number four in the batting order.
While there were several cameos, Curran lacked support as England fell 10 runs short of overhauling their opponents' 176 for seven to fall 2-0 down in the five-match series after losing the ODIS 2-1.
The tourists struggled left-arm spinners against Gudakesh Motie and Akeal Hosein, who leaked a combined 33 in eight overs. Motie was especially successful, taking 4-0-9-1 on a tricky pitch to bat on.
"No one likes losing," said Mott. "We played good cricket again for 90 per cent of the match. We had them under control up to the 15th-over mark and unfortunately, as West Indies can do, they hurt us.
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