Members of the Rail, Maritime and Transport union (RMT) at Network Rail and 14 train operators will stage two 48-hour walkouts from Tuesday and Friday, while drivers in the Aslef union will strike on Thursday.
Passengers, including those returning to work after the festive break, are being warned to expect "significant disruption" as only a limited number of trains will run.
The advice is to only travel if absolutely necessary, allow extra time and check when first and last trains will depart.
There may also be disruption to services on Sunday, January 8 as the striking workers return to their duties.
On RMT strike days, around half of the network will shut down and only about 20% of normal services running.
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