England ended day two in Rawalpindi with pressure piling up, trailing by 53 after losing three second-innings wickets in nine overs before the close.
They had earlier let a promising position slip as centurion Saud Shakeel (134) lifted the hosts from a shaky 177 for seven to 344 all out.
Wicketkeeper Jamie Smith had earlier put him down on 26 and he cashed in brilliantly, sharing partnerships totalling 160 with the tail.
Joining Shakeel in a crucial ninth-wicket stand of 72 was Sajid, whose striking facial hair, provocative celebrations and haul of 16 wickets since being recalled in Multan last week have cast him a central figure in the drama.
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