Adam Keighran blazed over from halfway for the opener and added further conversions to tries from Junior Nsemba, Brad O'Neill and Bevan French.
Salford coped better with the second-half conditions and temporarily reduced the deficit through Ollie Partington but Wigan were never in danger of surrendering a third top-flight win in a row.
Coming off a heavy defeat at Leigh two weeks ago, Salford started in sluggish fashion and were punished by a Wigan side who looked ruthless and ready to rack up a comprehensive win.
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