The Leeds-born 37-year-old, who has a record 369 appearances for his club side Quins, appeared in all five of England's matches during this year's Guinness Six Nations, including his 100th cap in the 23-22 win over Ireland.
He posted on Instagram: "To play for England once was a dream come true. Never in my wildest dreams did I think I'd get the opportunity to do it over 100 times. After a lot of reflection the past few months, the time feels right for myself and the team, to retire from international rugby.
"The past 12 months in this England team have been arguably my favourite, making memories that my family and I will cherish and remember for ever."
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