The Arsenal forward came off in the first half of the Gunners' 2-1 Champions League defeat at Lens on Tuesday night.
Saka suffered a hamstring injury and boss Mikel Arteta admitted it was a concern ahead of Arsenal's Premier League clash with Manchester City on Sunday.
Doubts over Saka's fitness could open the door for Newcastle's Anthony Gordon after his impressive start to the season.
Winger Gordo helped England Under-21s win Euro 2023 in the summer and has two goals and two assists in the league.
Aston Villa's Ollie Watkins is pushing for a recall with seven goals in all competitions this season, including two hattricks after his treble in the 6-1 thumping of Brighton on Saturday.
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