Quins' last victory over their London rivals came in January 2020. Sarries secured comprehensive victories last season - 3810 away and 52-7 - resulting in Wilson issuing a rallying call to his squad ahead of today's game.
He said: "I don't think we did ourselves justice against them last year and we certainly want to do that at home. We must put in a good performance our fans can be proud of."
Saracens go into this round of matches top of the table after three bonus point wins proving there is life after Owen Farrell and the Vunipola brothers.
Wilson said: "They're a very well-coached side full of quality rugby players. Although they've lost a few players, when you look at what they've replaced them with and what's coming through, there's some real quality. They've always been a strong Premiership team."
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