HIV first-in-class pipeline sees high levels of innovation that targets drug resistance and latency reversal

There are 87 first-in-class products that act on a range of 50 molecular targets, which can broadly be classified as host or viral factor

The human immunodeficiency virus (HIV)pipeline is robust, with 450 products in active development that display a high degree of novelty and diversity. Promisingly, there are 87 first-in-class products that act on a range of 50 molecular targets, which can broadly be classified as host or viral factors, indicating a high level of innovation in comparison with the marketed products, says GlobalData, a leading data and analytics company.

The company’s recent report, ‘HIV: First-in-Class Therapies Target Major Unmet Needs Including Drug Resistance and Latency Reversal’, reveals that the majority of the 10 highest-ranking targets have demonstrated evidence, either in vitro or in vivo, of latency-reversing potential and/or efficacy in drug-resistant HIV strains. This encouraging trend demonstrates that first-in-class innovation is centered on addressing these major unmet needs in the HIV market.