In early 2021, Dr. Michael Ombrello, an investigator at the National Institutes of Health, received a message from doctors at Yale about a patient with a novel genetic mutation—the first of its kind ever seen. A specialist in rare inflammatory and immune disorders, Ombrello was concerned by what first-round genetic tests showed: a disabling mutation in a gene, known as PLCG2, that’s crucial for proper immune functioning. It was hard to discern how the patient, a forty-eightyear-old woman, had survived for so long without serious infections. Even more puzzling was the sudden onset of severe joint pain and swelling she was experiencing after years of excellent health. He decided to bring her to the N.I.H. campus, in Bethesda, Maryland, to study her case first hand.
That’s how I ended up as a patient in his clinic on a sweet, warming day in April, 2021, just as the cherry blossoms in the Washington area were in full bloom. As a historian and a biographer, I am used to conducting research, examining other people’s lives in search of patterns and insights. That spring, I became the research subject. At the N.I.H., Ombrello’s team took twenty-one vials of my blood and stored a few of them in liquid nitrogen for future use. Scientists outside the N.I.H. began to study me, too. In the past few years, my case has been examined by specialists at Yale, Harvard, Columbia, and the University of Pennsylvania—by immunologists, rheumatologists, dermatologists, pulmonologists, and experts in infectious disease. It has been debated at hospital grand rounds and global medical conferences, and in high-powered conference calls. There are PowerPoint decks about it.
この記事は The New Yorker の January 30, 2023 版に掲載されています。
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この記事は The New Yorker の January 30, 2023 版に掲載されています。
7 日間の Magzter GOLD 無料トライアルを開始して、何千もの厳選されたプレミアム ストーリー、9,000 以上の雑誌や新聞にアクセスしてください。
すでに購読者です? サインイン
President for Sale - A survey of today's political ads.
On a mid-October Sunday not long ago sun high, wind cool-I was in Harrisburg, Pennsylvania, for a book festival, and I took a stroll. There were few people on the streets-like the population of a lot of capital cities, Harrisburg's swells on weekdays with lawyers and lobbyists and legislative staffers, and dwindles on the weekends. But, on the façades of small businesses and in the doorways of private homes, I could see evidence of political activity. Across from the sparkling Susquehanna River, there was a row of Democratic lawn signs: Malcolm Kenyatta for auditor general, Bob Casey for U.S. Senate, and, most important, in white letters atop a periwinkle not unlike that of the sky, Kamala Harris for President.
LIFE ADVICE WITH ANIMAL ANALOGIES
Go with the flow like a dead fish.
CONNOISSEUR OF CHAOS
The masterly musical as mblages of Charles Ives
BEAUTIFUL DREAMERS
How the Brothers Grimm sought to awaken a nation.
THE ARTIFICIAL STATE
A different kind of machine politics.
THE HONEST ISLAND GREG JACKSON
Craint did not know when he had come to the island or why he had come.
THE SHIPWRECK DETECTIVE
Nigel Pickford has spent a lifetime searching for sunken treasure-without leaving dry land.
THE HOME FRONT
Some Americans are preparing for a second civil war.
SYRIA'S EMPIRE OF SPEED
Bashar al-Assad's regime is now a narco-state reliant on sales of amphetamines.
TUCKER EVERLASTING
Trump's favorite pundit takes his show on the road.