It was a typically high-octane 90 minutes between two big hitters from the Premier League. However, there were not too many clear-cut chances at either end before Ake struck from a set-piece.
Bernardo Silva and Kevin De Bruyne went close in quick succession with Ake eventually settling the scores to see treble-winners City through to the next stage.
Here, we take a closer look at five talking points from the tie as City prepare to go into the fifth-round hat;
â BOBB COULD HAVE STOPPED VAR CALL?
Oscar Bobb was chosen to start the game and, despite what Pep Guardiola said in his pre-match interview, it was reward for the Norway youngster amid his continued development.
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We are fragile but we cannot overreact-Pep
PEP Guardiola says that City cannot afford to overreact to their worst ever run under his management as they look to stay in touch with Premier League leaders Liverpool.
ITâS TOO EASY TO SCORE AGAINST USâ
PEP Guardiola says City have multiple problems as opponents find it too easy to score against them.
Spurs man on the holeâ in City middle
JAMES Maddison has explained that he was able to exploit the lack of presence in City's midfield to score a goal that he has been working on all season.
Rubet! Amorim up for United challenge
RUBEN Amorim is relishing the 'huge responsibility' of taking United back to the top as the new head coach prepares to take charge for the first time at Ipswich.
'Ruthless' Ruben won't be all smiles as he gears up for first game at helm
\"I CAN be ruthless when I have to be,\" said Ruben Amorim on Friday afternoon.
Teenage star Chido on target once again
CHIDO Obi-Martin was again among the goals as United's Under-18s continued their stunning form and a new star emerged.
Tourist traps top visitor spend table
SEPARATED by the Pennines and nearly 100 miles, the historic city of York and the seaside resort of Blackpool are worlds apart in their appeal to tourists.
Wind farm expansion plan set to create new turbulence
Proposals would create biggest turbine development in England
Rail services may take 'three years to improve'
THE largest rail company in the North of England has warned that it will take up to three years before its services are up to scratch.
Thug forced kids to help in drug deals
A MAN who used 'vulnerable' children to help him deal drugs has been jailed.