Unbeaten in Germany last season, Xabi Alonso's side have battled to narrow wins in the German Supercup, German Cup and in their Bundesliga opener this season.
In Leipzig, they face a title rival for the first time.
The two league fixtures between the clubs last season proved crucial milestones in Leverkusen's breakthrough title.
In the Bundesliga opener last year, Leverkusen won 3-2 against Rose's German Cup Marco holders.
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Ghaaleb to extend Costa's lead
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