Skin aging is a culmination of genetic and environmental factors and is largely influenced by the cumulative damage from exposure to ultraviolet (UV) radiation.
The structural integrity of the skin is formed primarily by collagen. UV radiation exposure can induce tremendous insult to the skin through various mechanisms. One understood mechanism involves the generation of reactive oxygen species (ROS). Excessive ROS are harmful to the skin because they can cause oxidative damage to cells thus contributing to collagen breakdown.
DIFFERENT KINDS
With chronological aging, exacerbated by photoaging, collagen synthesis is reduced. Increased collagen breakdown coupled with decreased neo-collagenesis results in the integrity of the dermis being compromised and the reparative response becoming defective.
The joint result of these combined mechanisms is visible skin damage evident as wrinkles. Advancing age results in natural cellular attrition and senescence that must also be acknowledged as contributors to the clinical manifestations of skin aging.
The specific histological changes in the skin caused by photoaging are distinct from those that occur due to chronological aging.
In chronologically-aged skin, collagen fiber bundles are loose, short, and thin and disorganized when compared to sun protected young skin. The epidermis is thinner, and the number of rete pegs is reduced.
In contrast, photo-damaged skin is marked by elevated elastosis and collagen fragmentation beneath the dermal-epidermal junction. The epidermal thickness can be irregular, as can the morphology of epidermal cells.
CASE-TO-CASE
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Denne historien er fra July 2021-utgaven av Lifestyle Asia.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
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BAUTISTA-OSMEÑA
A Simple Affair
INSPIRATIONAL BEAUTY
What JEWELMER’s stunning pieces and Miss Universe Philippines Beatrice Luigi Gomez stand for is a life filled with peace, harmony, courage, and passion.
LIVING LIFE LIKE NO OTHER
VICTOR CONSUNJI shares how VCDC simply doesn’t build houses. Instead, they help build better lives
ADORNED WITH THE STARS OF LOVE
Cartier’s Love Is All doesn’t just boast a star-studded cast of characters from different walks of life; it also packs a powerful message succinctly in-tune to the 1974 Roger Glover pop hit
DIGITAL TRANSFORMATIONS AND WIN-WIN SITUATIONS
EEI Corporation has intensified its digital transformation following positive gains for both its clients and the economy.
RUN WITH PURPOSE
TIM YAP shares the amount of work he had to do to check the New York Marathon off his bucket list, and why he was running for more than himself
CHANGE IS COMING
JUANA MANAHAN-YUPANGCO believes in the healing power of knowing what you eat, sharing that knowledge and your blessings with others, and the timelessness of sticking to your passions
OPEN SECRET
Hidden in a sprawling forest, LIHIM RESORT offers a luxuriously private accommodations and fantastic views of El Nido
SUN TO SEA
Shangri-La Boracay’s Villa Collections are designed to offer guests distinct island experiences.
TRUST AND TRIUMPH
As the CEO of TransUnion, Pia Arellano leads the mission to instill trust in the ever-changing financial services industry