![LGA-ORD](https://cdn.magzter.com/1422886351/1723445392/articles/c-YOSEbi71723459075001/LGAORD.jpg)
“I hope I am not too old to take it up seriously nor too stupid about machines to qualify as a commercial pilot.”
—“Samuel Beckett,” by Deirdre Bair.
Gray bleak final afternoon ladies and gentlemen this is your captain your cap welcoming you aboard the continuation of Flyways flight 185 from nothingness to New York’s Laguardia non non non non non non nonstop to Chicago’s Ohare and on from there in the passing of gray afternoons to empty bleak eternal nothingness again with the Carey bus the credit-card machine the Friskem metal detector the boarding pass the in-flight magazine all returned to tiny bits of grit blowing across the steppe for ever
(Pause)
Cruising along nicely now.
(Pause)
Yes cruising along very nicely indeed if I do say so myself.
(Long pause)
Denne historien er fra August 19, 2024-utgaven av The New Yorker.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
Allerede abonnent ? Logg på
Denne historien er fra August 19, 2024-utgaven av The New Yorker.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
Allerede abonnent? Logg på
![Drug of Choice - The natural world contains many billions of potential medications. The question is how to find the ones that work.](https://reseuro.magzter.com/100x125/articles/8859/1818953/4g3NsKO7n1725344270057/crp_medicine-AI-antibiotics-medicines-drugs-origins-drugs-from-Dirt-aloe-vera-morphine-codeine-Ozempic-sources-of-medicine-microbes-medicine-history-Jan-Burian-technology-bacterias-DNA-Robert-Boer-chemical-hardware.jpg)
Drug of Choice - The natural world contains many billions of potential medications. The question is how to find the ones that work.
AI. is transforming the way medicines are made. Bacteria produce numerous molecules that could become medicines, but most of them aren’t easily identified or synthesized with the technology that exists today. A small percentage of them, however, can be constructed by following instructions in the bacteria’s DNA. Burian helped me search the sequence for genes that looked familiar enough to be understandable but unfamiliar enough to produce novel compounds. We settled on a string of DNA that coded for seven linked amino acids, the same number found in vancomycin. Then Burian introduced me to Robert Boer, a synthetic chemist who would help me conjure our drug candidate.
![Screams from a Marriage](https://reseuro.magzter.com/100x125/articles/8859/1826433/3zRgYYnN-1725881148238/SCREAMS-FROM-A-MARRIAGE.jpg)
Screams from a Marriage
‘Beetlejuice Beetlejuice.”
![Fly with Me](https://reseuro.magzter.com/100x125/articles/8859/1826433/dYeQQzK6j1725880676447/FLY-WITH-ME.jpg)
Fly with Me
The children’s books of Katherine Rundell.
![The Mystery of Pain](https://reseuro.magzter.com/100x125/articles/8859/1826433/e8e1WRybK1725879059454/THE-MYSTERY-OF-PAIN.jpg)
The Mystery of Pain
Garth Greenwell’s novel of extreme affliction and ordinary happiness.
![The Show Must Go On](https://reseuro.magzter.com/100x125/articles/8859/1826433/8Ifks8k251725878208364/THE-SHOW-MUST-GO-ON.jpg)
The Show Must Go On
What if Ronald Reagan’ Presidency never really ended?
![LAST COFFEEHOUSE ON TRAVIS](https://reseuro.magzter.com/100x125/articles/8859/1826433/2arIF1NQM1725877039050/LAST-COFFEEHOUSE-ON-TRAVIS.jpg)
LAST COFFEEHOUSE ON TRAVIS
For a few months, I stayed with my aunt's friend in Midtown, back when she could still afford to live there.
![Tales from the New World](https://reseuro.magzter.com/100x125/articles/8859/1826433/FUEtmPGZg1725876059710/TALES-FROM-THE-NEW-WORLD.jpg)
Tales from the New World
The novelist Richard Powers considers our changing earth.
![Land of the Flea](https://reseuro.magzter.com/100x125/articles/8859/1826433/xk--ld-TU1725873820810/LAND-OF-THE-FLEA.jpg)
Land of the Flea
What America 1s buying and selling.
![The Dark Time](https://reseuro.magzter.com/100x125/articles/8859/1826433/V6UjUCdK01725867416552/THE-DARK-TIME.jpg)
The Dark Time
On the Arctic border of Russia and Norway, an espionage war is emerging.
![The Post-Moral Age](https://reseuro.magzter.com/100x125/articles/8859/1826433/6J5KQks7M1725866971231/THE-POSTMORAL-AGE.jpg)
The Post-Moral Age
If conscience is merely a biological artifact, must we give up on goodness?