In early 2021, Dr. Michael Ombrello, an investigator at the National Institutes of Health, received a message from doctors at Yale about a patient with a novel genetic mutation—the first of its kind ever seen. A specialist in rare inflammatory and immune disorders, Ombrello was concerned by what first-round genetic tests showed: a disabling mutation in a gene, known as PLCG2, that’s crucial for proper immune functioning. It was hard to discern how the patient, a forty-eightyear-old woman, had survived for so long without serious infections. Even more puzzling was the sudden onset of severe joint pain and swelling she was experiencing after years of excellent health. He decided to bring her to the N.I.H. campus, in Bethesda, Maryland, to study her case first hand.
That’s how I ended up as a patient in his clinic on a sweet, warming day in April, 2021, just as the cherry blossoms in the Washington area were in full bloom. As a historian and a biographer, I am used to conducting research, examining other people’s lives in search of patterns and insights. That spring, I became the research subject. At the N.I.H., Ombrello’s team took twenty-one vials of my blood and stored a few of them in liquid nitrogen for future use. Scientists outside the N.I.H. began to study me, too. In the past few years, my case has been examined by specialists at Yale, Harvard, Columbia, and the University of Pennsylvania—by immunologists, rheumatologists, dermatologists, pulmonologists, and experts in infectious disease. It has been debated at hospital grand rounds and global medical conferences, and in high-powered conference calls. There are PowerPoint decks about it.
Denne historien er fra January 30, 2023-utgaven av The New Yorker.
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Denne historien er fra January 30, 2023-utgaven av The New Yorker.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
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The Football Bro - Pat McAfee brings a casual new style to ESPN.
If, on a cool weekend morning in autumn, you happen to be watching “College GameDay,” on ESPN, don’t worry about figuring out which of the broadcasters behind the improbably long desk is Pat McAfee. He’s the one with the roast-pork tan, his hair cut high and tight, likely tieless among his more businesslike colleagues. The rest of the onair crew—Lee Corso, Rece Davis, Kirk Herbstreit, Desmond Howard, and, newly, the former University of Alabama coach Nick Saban—tend to look and dress and talk like participants in an old-school Republican-primary debate. McAfee, though, favors windowpane checks on his jackets and a slip of chest poking out from behind his two or three open buttons. If the others are politicians, he’s the cool-coded megachurch pastor who sometimes acts as their spiritual adviser.
The Dark Time. - On the Arctic border of Russia and Norway, an espionage war is emerging.
On the Arctic border of Russia and Norway, an espionage war is emerging. The point of contact between NATO and Russia's nuclear stronghold is the small town of Kirkenes. For years, Russia has treated the area as a laboratory, testing intelligence and influence operations before replicating them across Europe.
MIRROR IMAGES
‘A Different Man” and The Substance.”
OTHER PEOPLE'S MONEY
Proximity to wealth proves perilous in Rumaan Alam’ novel Entitlement.”
EYES WIDE SHUT
How Monet shared a private world.
WITH THE MOSTEST
The very rich hours of Pamela Harriman.
HUGO HAMILTON AUTOBAHN
On the Autobahn outside Frankfurt. November. The fields were covered in a thin sheet of snow.
TRY IT ON
How Law Roach reimagined red-carpet style.
SORRY I'M NOT YOUR CLOWN TODAY
Bowen Yang's trip to Oz, by way of conversion therapy and S..N.L.”
SNIFF TEST
A maverick perfumer tries to make his mark on a storied fashion house.