The Scourge of All Humankind
If you were, for whatever macabre reason, seeking the most catastrophic moment in the history of humankind, you might well settle on this: About 10,000 years ago, as people first began to domesticate animals and farm the land in Mesopotamia, India, and northern Africa, a peculiar virus leaped across the species barrier. Little is known about its early years. But the virus spread and, whether sooner or later, became virulent. It ransacked internal organs before traveling through the blood to the skin, where it erupted in pus-filled lesions. Many of those who survived it were left marked, disfigured, even blind.
As civilizations bloomed across the planet, the virus stalked them like a curse. Some speculate that it swept through ancient Egypt, where its scars appear to mar the mummified body of Pharaoh Ramses V. By the fourth century A.D., it had gained a foothold in China. Christian soldiers spread it through Europe during the 11th- and 12th-century Crusades. In the early 1500s, Spanish and Portuguese conquistadors conveyed it west across the Atlantic, where it ravaged native communities and contributed to the downfall of the Aztec, Mayan, and Inca empires.
By the end of the 1500s, the disease caused by the virus had become one of the most feared in the world. About a third of those who contracted it were dead within weeks. The Chinese called it tianhua, or "heaven's flowers." Throughout Europe, it was known as variola, meaning "spotted." In England, where doctors used the term pox to describe pestilent bumps on the skin, syphilis had already claimed the name "the great pox." And so this disease took on a diminutive moniker that belied the scale of its wretchedness: smallpox.
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