Dozens more were killed in separate strikes in central Gaza yesterday, local reports said.
Israel's military said it made a "targeted" attack on the school in the Nuseirat camp, which it said housed a "Hamas compound".
Hamas accused the Jewish state of committing a "horrific massacre".
The major new push against the terror group in the centre of the wartorn Gaza Strip comes in the face of renewed efforts by the US to secure a lasting ceasefire.
Israel's military confirmed the strike on the school, which was housing displaced Palestinians, before key talks between American and Qatari mediators to try to finalise a peace deal.
Local sources said an Israeli warplane fired two missiles at classrooms on the top floor of the school.
Ambulances and rescue teams were seen rushing the wounded and dead to a nearby hospital.
Footage showed destroyed classrooms and bodies wrapped in shrouds at a mortuary.
Brutal
In one video, an injured woman screams: "Enough war! We have been displaced dozens of times.
"They killed our children while they were sleeping." Hamas media office director Ismail al-Thawabta denied the school had a hidden terror command post.
Denne historien er fra June 07, 2024-utgaven av Daily Express.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
Allerede abonnent ? Logg på
Denne historien er fra June 07, 2024-utgaven av Daily Express.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
Allerede abonnent? Logg på
Howe defends spent promises
'RULE CHANGES HURT TOON'
Business as usual for Tigers despite missing Cheika
MICHAEL CHEIKA'S right-hand man at Leicester shrugged off the head coach's absence from today's clash at Newcastle after his touchline ban.
Ex-policewoman charged after paddleboard tragedy
A FORMER policewoman has been charged with gross negligence manslaughter following the deaths of four people in a paddleboarding incident.
Country star lashes out at 'hush money' rape claims
COUNTRY singer Garth Brooks has insisted that rape claims made against him by a stylist are a \"hush money\" shakedown.
Michel Roux: 'Potato Gate exit from BBC still hurts
MICHEL Roux Junior is still simmering at the BBC 10 years after he says he was forced out of MasterChef over a \"Potato Gate\" row.
Airstrikes threaten evacuations
IRAN'S CALL TO ARMS AS BRITISH AND U.S. HIT HOUTHI TARGETS
MONTELL: I'VE BEATEN THE BEST...BUT I'VE MET MY MATCH DANCING IN HEELS
SHE is formidable as Fire on TV's Gladiators, but Montell Douglas has finally met her match on Strictly-high heels.
PM's £22bn bid to capture carbon
SIR Keir Starmer rubbed shoulders with factory workers as he pledged nearly £22billion to capture and store carbon emissions from energy, industry and hydrogen production.
APOLOGY AFTER PROBE FINDS WOMEN SUBMARINERS SUFFERED MISOGYNY AND BULLYING
NAVAL personnel have been sacked after a probe uncovered \"intolerable\" misogyny and bullying on board nuclear-armed submarines.
Boris: Cameron wrong to quit after EU vote
BORIS Johnson has criticised David Cameron for quitting as PM after Britain voted to leave the European Union.
