Interim head coach Van Nistelrooy will hand over the reins to Ruben Amorim this week and wait to find out if he still has a job.
He will leave behind a team unbeaten in his four games, and with some momentum and goals behind them at last.
Bruno Fernandes opened the scoring inside 20 minutes with a delightful finish, to celebrate his 250th United appearance in style.
An own-goal from Victor Kristiansen doubled their advantage, before substitute Alejandro Garnacho sealed Leicester's fifth league defeat of the season with a stunning strike.
Van Nistelrooy had dropped Garnacho in favour of Amad Diallo, who scored twice in the win against PAOK in the Europa League last Thursday.
Centre-back pair Lisandro Martinez and Matthijs de Ligt were also recalled.
Denne historien er fra November 11, 2024-utgaven av Daily Express.
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Denne historien er fra November 11, 2024-utgaven av Daily Express.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
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Hands-on Arteta already planning for the next era
MIKEL ARTETA celebrates his 250th game in charge of Arsenal today - and has already mapped out the future with the Gunners hierarchy.
Unai said: Until you can prove yourself you're a Championship player in my eyes
TOUGH love has transformed Morgan Rogers into a Premier League thoroughbred.
No place like a prize home for Omaze winner
ECSTATIC Sarah Perry has won a £500,000 home near her Powys roots in an Omaze draw and given her husband the shock of his life.
Back beside the seaside 52 years on
FUN-LOVING pals reshot a snap from their first holiday together - 52 years ago.
'Harshita, you left this world but are still in our hearts'
Family's tribute to body-in-boot wife
Factory farming costs taxpayer £1bn a year
THE factory farming of animals costs taxpayers almost £1billion a year, a study has found.
'Our beautiful one-of-a-kind Simone had a spark for life'
THE parents of a British lawyer who died after allegedly being served drinks laced with methanol in Laos say they are \"devastated by the loss of our beautiful, kind and loving daughter\".
Strictly Sarah: I didn't believe I could do lifts ...but look at me now
NEWLY confident Sarah Hadland has ditched her panic about bare legs, fake tans and doing ballroom lifts to become a firm favourite to win Strictly Come Dancing.
Down thunder! Aussie TV camp soaked
THE I'm a Celebrity...Get Me Out of Here! camp has been battered by torrential rain, which could lead to the contestants being evacuated.
300 jabs a minute to event tripledemic’
AN NHS vaccination blitz is delivering more than 300 jabs a minute to tackle a deadly \"tripledemic\" of flu, Covid and respiratory syncytial virus.
