Pep Guardiola's side are still buoyed by the dominant 3-0 win over rivals United on Sunday, with Phil Foden adding to Erling Haaland's brace on an excellent afternoon at Old Trafford.
The players have had almost a full week to recover as well, having been eliminated from the Carabao Cup in the last round.
With Arsenal and Tottenham not in action until Saturday evening and Monday night respectively, City can return to the top of the Premier League with victory this afternoon.
Haaland will also hope to continue his improving record in front of goal.
ALVAREZ AND HAALAND
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