The captain has travelled to the Greek capital and is not believed to have an injury, with the selection news understood to have caused surprise within a dressing room that has been undermined by a flurry of withdrawals.
Carsley has been keen to try new things during his interim tenure; he started Jude Bellingham and Phil Foden as false nines in an ultra-attacking lineup against Greece at Wembley last month - which ended in a disastrous 2-1 defeat.
He is plainly undeterred and is expected to prefer Ollie Watkins in the No 9 role this time.
Kane has never made any secret about England always coming first for him and, in an interview he prerecorded with ITV on Tuesday, he worried whether some of his teammates feel the same, saying that club should never come before country.
Carsley has seen nine players withdraw from his final squad in interim charge - some are clearly injured but others risk being accused of taking advantage of the situation.
Denne historien er fra November 14, 2024-utgaven av The Guardian.
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Denne historien er fra November 14, 2024-utgaven av The Guardian.
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Bentancur to get long ban over alleged racist remark
Tottenham are resigned to Rodrigo Bentancur being given a lengthy ban of at least six matches by the Football Association for making an allegedly racist remark about Son Heung-min.
Kane faces Carsley axe Shock as captain set to be left out for crunch Greece match
Harry Kane is set to be a shock omission from Lee Carsley's England team for tonight's must-win Nations League match against Greece in Athens.
Infantino to avoid scrutiny with virtual 2026 draw
Gianni Infantino will avoid any scrutiny of the controversial decision to give the 2034 World Cup to Saudi Arabia next month after Fifa opted to stage the qualifying draw for the 2026 tournament as a virtual event.
Gordon heeds England's call as no-shows hinder Carsley
While a depleted side face tricky tests against Greece and Ireland, there will be big opportunities for some
Lawrence caps quick Chelsea comeback after Agnew's early strike
Chelsea's aspiration of claiming this season's Women's Champions League was hardly in danger as Murphy Agnew handed Celtic a shock lead.
Paul's big-money fight is a circus but the YouTuber is no clown
Despite the absurd persona, his business savvy and support of female fighters must be acknowledged
Tyson offers reminder of boxing's glory days before weary return
Former Baddest Man on the Planet is reflective but determined in open workout as he gears up for inglorious fight with YouTuber, reports
Lineker leaves second BBC presenting role
Gary Lineker has stepped down from his role as presenter of Sports Personality of the Year (Spoty), the BBC has confirmed.
Coe pulls no punches with his IOC pitch
Sebastian Coe has promised to introduce an \"uncompromising and clearcut\" policy to protect women's sport and to look into awarding prize money to all Olympic medallists if he is elected International Olympic Committee (IOC) president.
Slade vows 'not to shut up shop' against Springboks
England are looking to banish their autumn frustrations at South Africa's expense this Saturday and have vowed \"not to shut up shop\" against the reigning world champions.